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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

她说:”波比就像是小碧昂斯,一个小淑女。”
每到仲夏时节,这家企业数据存储公司就会通过举办“狗狗节”来提升士气。员工此时可带着自己的宠物上班,欣赏宠物商品展销会,当地的宠物美容师、宠物商店老板以及驯兽师都会参展,还可以观赏狗狗才艺表演。在“狗狗节”前一周会有一场彩票抽奖活动,全部收入都将捐献给当地的动物慈善机构。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

8.Please aid the Olympic authorities and organisers by demonstrating at all times that you are not a terrorist. Do not perspire, take off your shoes, smile in a weird way while texting someone, or point and shout: "Hey! Look at all those missiles on that roof over there!" In fact, if you're not using your hands for anything, it's probably best if you keep them in the air where everybody can see them.
中国厂商:中国汽车进军美国?巴菲特持股的比亚迪汽车公司称,它将于2015年登陆美国市场,吉利汽车也将于2016年进入美国市场。不过自2006年起,我们就一直在听说中国车企要登陆美国。中国汽车最大的硬伤是做工问题。中国有80多家汽车厂商,生产的车型多达524款,研发资金铺得太开,太单薄,以至于很难获得有意义的业绩。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

1月份,中国的进口同比减少了14.4%,降至7375亿元人民币。大于去年12月4%的降幅,也和上升1.8%的预期不符。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

*最佳综艺导演:瑞安?麦克福(Ryan McFaul),《艾米?舒莫的内心世界》(Inside Amy Schumer)

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels
吉迪恩拉赫曼(Gideon Rachman)
Hillary stays on: Clinton’s CV is chock full of firsts: The only first lady to become a U.S. senator turned viable presidential candidate turned secretary of state. Now a private citizen, she continues to be one of the most watched and listened-to women on the planet. All bets on that she will be the 2016 Democratic presidential candidate and the free world’s presumptive next leader. She’s done little to quiet the chatter, including hitting the speaking circuit last month at an estimated $200,000 fee per event and inking a reported $14 million book deal.
Having earned a living for the last four years while her contemporaries go to school every day, she has been forced to mature quickly.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

凯特哈德森接受ELLE专访谈感情
上榜理由:食物、文化和恐怖故事
The most exciting part is the offseason
[f?'siliteit]

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

宝能投资集团董事长姚振华是2015年财富榜的黑马,他的财富在一年之内上升了820%,达到172亿美元,使他上升到财富榜第四位。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

In the past two decades, several campus poisoning incidents have sparked mass debates and concerns about students' psychological development and support.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 中国矿主的突围之路
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

但是,欧洲央行宣布决定后市场暴跌。投资者抱怨称,这家央行此前在其准备注入多少额外刺激以支撑复苏的问题上误导了市场。
这是两部后自语核(post-mumblecore)喜剧,讲述自我认知及其边界的故事。布西内斯克的影片是完美的怪人三角,三条边分别是盖·皮尔斯(Guy Pearce)、寇碧·史莫德斯(Cobie Smulders)和凯文·科利根(Kevin Corrigan),以德克萨斯州奥斯汀怪人们轻松胡混的伪装出现。皮文的影片探索精神病以及日间电视节目的的黑暗疆域。由于克里斯汀·韦格(Kristen Wiig)的精彩演出(她饰演一个名叫爱丽丝·克里格的彩票得主),《欢迎来到我的世界》成了关于美国梦想者的精彩肖像,既令人不安,也鼓舞人心。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

当时的杜兰特身高6尺9寸,体重只有185磅,我很惊讶在高中赛打到一半时他没有被撞坏。幸运的是,杜兰特不靠在大前锋位置上力量抗衡赚钱,他主要依赖他拿手的急停跳投。
“当她穿着华丽的衣服站在舞台上,她神采奕奕的表情对我来说是无价之宝。”

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

《银河护卫队》之所以能成为一部大获成功的超级英雄系列电影,原因之一就是它的幽默感。这部影片充满了自嘲和讽刺。观看这部影片的时候,你不会一直笑个不停,但至少会有一些瞬间让你哈哈大笑,比如树人和克里斯?帕特出场的时候。
"没人能阻止行动,我会用生命为代价一直投放宣传单张到北韩,"Park说,强调他一直有对抗北韩威胁的准备。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

'People go crazy and it gets overwhelming.'
vt. 超过,胜过,超出界限
The number of people living in poverty in rural areas was reduced by 12.4 million.
Li Jianmin, from the local Public Security Bureau, told Xinhua news agency, quoted by the South China Morning Post: 'The entire processing facility had a fishy and foul smell. You just couldn't stand it after one or two minutes.'

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

McCarthy took home $33 million in earnings, up $10 million from 2015.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

据新华社报道,2015年教育部和其他5个中央政府部门一起组成了一个专门工作组,以保障足球在中国学校里的蓬勃发展。
反对:在颁奖季前一年早早上映可能不利于其冲奖。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

?007 is almost always calm. (Maybe that's due to all the sex.) Even when people are trying to kill him he's calm. This is sexy. Bond doesn't move unnecessarily. You never see his knee bouncing or hands fidgeting. He speaks slowly and deliberately and is rarely rushed. These are all very charismatic qualities. He has the unflinching eye contact of a predator -- and this increases the chance women will fall in love with him. 007 doesn't gush over girls and show his feelings. He keeps them guessing and uncertainty increases attraction. Bond doesn't smile much and this too makes him sexy because happiness isn't alluring in men. His body language is commanding and he's not afraid to take up space, which is very masculine and appealing. 007 doesn't ramble on and this too is smooth. Bond never slouches. Good posture increases confidence, feelings of power and makes you physically tougher. (Which works out well when you want to look classy in your tuxedo while battling machete wielding evil minions.)

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

On Turkey, which recently shot down a Russian warplane, Putin said he sees no possibility of overcoming the strained ties with the current Turkish leadership. He said he was shocked to see that Turkey hadn't tried to explain its action but turned to help from NATO instead.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

For the New Yorkers who have turned their apartments into bed-and-breakfasts, the battle over illegal inns could reach a fever pitch. On top of it all, Mayor Bill de Blasio’s 10-year affordable housing plan will take shape just as legislation in Albany threatens to strain the pocketbooks of renters. These are among the game-changers looming as we ring in the New Year.
The U.S. is set to add nearly 3 million jobs in 2014 — the biggest increase since 1999. The burst in job creation, expected to continue in 2015, is sure to fuel consumer spending. So, too, will a plunge in gasoline prices that's given households extra cash to spare on other goods and services. See: Americans saved $14 billion as gasoline prices declined in 2014.
2011年在达洛伊西奥15岁时,他就曾获得来自李嘉诚的种子投资。一年之后Summy发布,并在短短一个月内吸引了500,000名用户,在28个国家登上了新款应用软件热度榜的首位。对于一个连高中都还没毕业的人来说,雅虎的收购可谓意义深远。不过,达洛伊西奥的过人之处可不只是技术知识丰富这一点。在他连胡子都不用刮的时候,他就强烈向往、渴望著有朝一日能在科技领域做出一番大的成就。不仅要创新,还要有所成就,当然,还要大把赚钱。
她和妹妹都是通过家庭辅导接受教育的。她的妹妹也出演了《Dance Moms》。去年,以两姐妹的名字创建的时尚品牌The Maddie & Mackenzie Collection问世。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

‘The Americans’ Set in the Reagan era, this FX series is nearly as deceptive as KGB agents posing as suburban American couple: In its second season, “The Americans” proved to be a drama about love, family, friendship and mistrust disguised as a Cold War thriller.
一些英国退欧派人士和共和党人相信绝对自由市场理念,
项目总成本:11.8万美元
Mr. Russell's 1970s Abscam fictionalization 'American Hustle' had the better night overall, winning acting awards for Amy Adams and Jennifer Lawrence. Best picture was the only award for '12 Years a Slave,' which came in with seven nominations, tied for the most with 'American Hustle.'
At its Worldwide Developer Conference in June, Mr Cook was mobbed by app makers who asked him to pose for selfies. By October’s iPad launch, he was even cracking jokes at his own expense. Clad in his habitual but unglamorous uniform of black untucked shirt and jeans, he said that Apple Watch had been well received by “people who know a lot about fashion and style — even more than I do”, pointing a knowing finger at the chuckling audience.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 找准落点深化农村土地制度改革
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

In a statement given to the website Kotaku, Epic Games said the lawsuit was a result of Mr Rogers "filing a DMCA counterclaim to a takedown notice on a YouTube video that exposed and promoted Fortnite Battle Royale cheats and exploits."
‘Hackers are using common terms from pop culture and sports to break into accounts online because they know many people are using those easy-to-remember words.’

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 家居建材产品“底价”大曝光
Critical Review

The role of biosensors in the detection of emerging infectious diseases

The 500 brands come from 28 different countries, among which nearly half, 227, are from the US.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 多方合力推动新型建材研发
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

其实,在第一部iPhone手机发布的前一年,LG集团已经推出了全触屏手机。虽然那也不是第一台触屏手机。1992年,世界上第一台触屏手机IBM Simon发布。而触屏技术在"西蒙"之前已经出现。1965年,E·A·约翰逊发明了第一个触屏设备——平板电脑,截止到1995年,一直由空中交通管制员使用。本特·斯顿普和弗兰克·贝克(Frank Beck)在20世纪70年代早期发明了电容式触屏,与约翰逊所发明触屏不同的是,它不能用手指操作,而是需要使用触控笔。在1971年,山姆·赫斯特发明了第一台电阻式触屏,他称之为"电子图表"。手指和触控笔都可以对它进行操作。在1985年,惠普公司发明了世界上第一台触屏电脑H-P150。在1993年,苹果公司也发布了第一个触屏设备——牛顿个人电子助理设备。但此产品并不成功,它的销量很低。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

I always judge the tank on actions and not by words. So, when teams say they're not in the tank and then run out a bunch of undrafted free agents while injuries to star players linger, that's when you know it's on.
Winners: Thunder
对工业大宗商品需求的下降尤为明显。中国房地产和制造业的严重供应过剩在近几个月抑制了对新产能的投资,进而削弱了对各种原材料的需求。
想知道2013年的最差工作是哪些吗?报社记者以其令人尴尬的特质,取代伐木工人成为今年的最差工作。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

re回+spond承诺→承诺回去;respond的名词→回答;答应
n. 污染,污染物
These are a few old shows that found new vigor in 2014 and deserve another look — and also a few that don’t.
它们大多来自50个不同的行业,包括食品和饮料、汽车和汽车零部件、媒体、零售、能源和互联网。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

8.Wheel Skates
“让人们感到不幸福的原因有很多——从贫穷,失业,家庭破碎到身体伤害” 报告声称,“但在一些特定的社会中,慢性的精神性疾病却是幸福的‘头号杀手’。如果我们想要一个更加幸福的世界,我们需要花更多努力来关心人们的心理健康。”

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

莱蒂齐娅·巴塔利亚按时间顺序为当地一家报纸记录了七八十年代巴勒莫的黑手党战争。如今,她的照片被一些博物馆和回顾展收录。
The clip, taken on a mobile phone, starts with the crowd singing the Frankie Valli lyrics: You're just too good to be true, can't take my eyes off of you'.
对于像费城、凤凰城和布鲁克林这样的烂队而言,另一个问题在于他们很难笼络到好的球队拼图。
China’s handling of its state reserves of raw materials such as cotton and sugar will be a key factor shaping the direction of agricultural commodities in 2017, according to a major lender to agribusinesses.
The rest of the top 10 2016 highest-paid actresses are:

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Chinese billionaire Wang Jianlin, whose company owns AMC Theaters climbed into the top 20.
setting
授完奖,在他致谢他的粉丝和MTV之前,他兴奋地说到”首先,我想说我不确定我怎么能得到这个奖,因为我已经好几年没有出过唱片了,但是我得奖了。”另外,Kendrick Lamar获得了最佳录影带奖,尽管这位说唱歌手无法到场,而是他通过视频感谢了他的粉丝。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Perhaps the more interesting question is what drove Yahoo! to shell out that reported $30 million for a single app. To be sure, Summly's text-compression abilities dovetail nicely with Yahoo!'s new focus on mobile utilities. Along with Yahoo!'s $1.1 billion purchase of the blogging service Tumblr and the launch of an acclaimed new weather app, the Summly move marks a commitment to owning the tiny real estate of the smartphone screen-and serving advertising to the youthful eyeballs that tend to gravitate to mobile devices.
The American share in the total drugspending is about one third. IMS experts estimate that in 2014 it will rise11.7 percent. The UShas particularly high prices, according to the report, but drug makers defendthis by citing the soaring cost of new medicine development.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

让爱情多姿多彩:荷兰培育出彩虹玫瑰(图)
四年前,玛蒂还是一个默默无闻的8岁小女孩,她喜欢跳舞,就读于当地一所小学。
我经常觉得不开心

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 扫二维码买家具 成都商家进军O2O
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

准备接收附近酒吧发布的微博广告吧
中国的旅游业官员正力图在2014年扭转入境游客减少的情况,专家认为,如果能对其过时的旅行团进行改进并降低票价,这一计划就有可能实现。
9月,苹果iPhone 6s和6s Plus发售,在中国创下销售记录。中国占苹果公司总营收的逾四分之一。在这里,苹果的产品往往被视为地位的象征,它的竞争对手不仅有来自韩国的劲敌三星(Samsung),还有日益流行的中国智能手机品牌华为和小米。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Over the first weekend of 2015 the second-largest bitcoin exchange, Slovenia-based Bitstamp, was victim of a hack to the tune of some $5 million U.S. dollars’ worth of the digital currency. As the tech press were quick to point out, it was a worrisome start to the year for a digital currency that Quartz had already declared “the worst investment of 2014.” And if you look at its performance between Jan 1, 2014 and Jan. 1, 2015, that’s not wrong: bitcoin ended the year at 39% of the value it started with.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
From the themed collection: 顺德人才租赁房:免租或半价租
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

recept接受+ive表形容词→善于接受的

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Additional reporting from Stefan Wagstyl in Berlin
I'm sure Dwight Howard's never used steroids, but it sure looks like he has. It looks like Howard doubled in size since leaving high school for the NBA.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

[?.s?usi'ein]
determine
还有些电视剧不如人们最初预料的好,不过仍有吸引力,最显眼的是映时频道的《婚外恋》,它一开始看起来像汉普顿斯式黑色电影,后来变成了法国艺术电影。剧中的罪行与过于缓慢的节奏以及《罗生门》(Rashomon)式的讲述方式不太相称,不过该剧在最后几集势头大涨,悬念丛生。
一个解释是,在金融业高薪领域工作的男性比例远远超过女性比例。三分之一的男性在私募、风险资本、投资银行或者并购以及对冲基金领域工作,而女性只有19%。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

在第七十届戛纳电影节的第一天,像艾米莉·拉塔基科斯基、阿德里亚娜·利马、莉莉·唐纳森以及皮德拉·尼姆科娃这样的人最终称霸红毯一点也不奇怪。
That even at a lower profit margin (say, 40%) and a 1/3 cannibalization rate (i.e. customers buy one third fewer full-priced iPhones), the cheaper iPhone would increase Apple'srevenue and gross profits (see her spreadsheet above).

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 家居电商化须探“特色”之路
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

WASHINGTON (MarketWatch) — The U.S. economy finally got a big jolt of energy in 2014 after the lamest recovery since World War II. And 2015 is shaping up to be an even better year.
6.《我爱你,菲利普·莫里斯》

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

参与本次突袭犯罪活动的警察说,他们还发现了牛百叶、软骨和其它早已过期的动物器官,这些都是从邻国越南走私来的。警方共查处非法肉类20吨。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

But the impact of corporate stinginess can go beyond simply ruining employees’ lunar new year holiday, possibly coming back to bite employers: 39 per cent of respondents said they would look for work elsewhere if their year-end bonus was not up to snuff, an increase of 2.3 percentage points from 2015.
[di'rekt?, dai'rekt?]
谁也不愿意自己的家门口整天闹个不停。
Consumer and producer prices are still either muted or in deflationary territory in China – but last month marked something of an uptick for each.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

It is not unusual for the documented wealth of China’s richest people to surge suddenly — or even for previously unknown tycoons to burst into prominence — as stock exchange listings and other public investments thrust them into the spotlight.
在星期六晚上他们再次献唱《悲惨世界》原声《Stars》。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
From the themed collection: 国内钛白粉价格持续下跌
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

调查指出,关键的是,世界的不稳定性和冲突可能继续推动通货膨胀并影响某些城市的生活成本。
伦敦博蒙特·内森顾问公司(Beaumont Nathan)的联合创始人雨果·内森(Hugo Nathan)说:“新投资者对早期绘画大师的作品有兴趣,不过他们想要的是杜维恩(Duveen)卖给强盗大亨们的作品。他们想要名作。”他指的是英国艺术交易商约瑟夫·杜维恩(Joseph Duveen),他把很多伟大的艺术品带去了美国。
“…started swearing during the interview.”

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

EMBAGlobal is the only programme in the top 10 that saw a slight drop in the average salary of its alumni compared with last year (the other nine recorded strong increases).
['t?ksik]
尽管通常每年的十大榜单中至少有四款引擎会在第二年再次上榜,但去年动力强劲的引擎中只有两款仍然出现在2014年榜单上,它们分别是本田雅阁(Accord)动力十足、节能高效的3.5升V6引擎以及奥迪S5所配备的强劲机械增压3.0升V6引擎。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

与此同时,中国12月消费者物价指数(CPI)略升至1.5%,11月为1.4%,为5年低点。
adj. 奢侈的,浪费的,过度的,大量的

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 白炽灯淘汰计划面临中期评估期
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

im不+mun=public公共的+ity→不公共→不和别人一样[得病]→免除;免疫
Dealers: Car dealers work toward reducing the paperwork involved in buying a car and the hours it takes to fill it out. That will give them more time to devote to upselling add-ons such as extended warranties, paint and fabric protection, and rust-proofing.
众所周知,蝙蝠侠的扮演者不再是克里斯汀·贝尔,而是肉肉的本·阿弗莱克。他将打败超人,拯救哥谭镇。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Islands in China come with many restrictions on their use and just 50 years of ownership.
Best wishes for the holidays and happiness throughout the New Year.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 家居市场景气指数现三连涨
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

ESCP Europe and MIT Sloan School of Management in the US also performed well. Both schools climbed five places into third and fifth place respectively.
曾发明Chapul蟋蟀蛋白棒的创业家帕特o克劳雷通过Bigcommerce来验证产品的早期市场兴趣,积攒市场人气,并且与健康食品商店和超市协商达成交易。虽然该团队有机会能以低得多的价格转至Shopify平台,但最近选择又一次与Bigcommerce续签。“我们认为,短期内我们的增长速度不会超过Bigcommerce,”他说。
['depjuti]

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

vi. 自制

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

confident
What’s more, a Fiat engine not only places among Wards’ top 10 for the first time, it’s for an electric motor, the 83-kW unit found under the hood of the diminutive 500e. Unfortunately the car is only sold in California, though market forces might convince the automaker to send it into wider distribution should gas prices gain spike up to the $4.00/gallon mark or above.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Taken together, these events and strategic initiatives highlight the Chinese aerospace industry’s realization that, in order to become a globally competitive player, it will need depth as much as breadth. After getting their hands on both ends of the value chain—aircraft design and final assembly—the Chinese now understand that what will make or break their industry over the long term is what happens in the middle of the value chain, at the component and subsystem levels. And that is why China’s ambition to compete with Boeing and Airbus, as well as with GE and Rolls-Royce for aircraft engines, is now more credible than ever.
I am so excited to be hosting the Oscars for the second time. You know what they say - the third time's the charm.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

3.在戛纳,他们说英语
变化世界中的得与失

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

跳水女皇郭晶晶2010年会否出嫁?
根据独立健康慈善金基金的分析,到2021年,医疗预算将持续缩减大概8亿欧元(超过10亿美金),尤其是在性健康和性传染病方面的缩减。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

这段深入11岁女孩心灵与情感的旅程可能是皮克斯迄今最疯狂的冒险。这是一部非常有趣的工作场合情景喜剧,艾米·波勒(Amy Poehler)、菲利丝·史密斯(Phyllis Smith)和敏迪·卡灵(Mindy Kaling)等人带来了精彩感人的演出,这是一则关于心理发展的精巧语言,也是对于悲伤在我们的生活中所扮演的角色的一种感人而诚恳的辩护。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

中国依然是美国政府债券的最大持有人,10月份中国也减持到1.25万亿美元。
The Harry Potter star Emma Watson hold fifth position in the list of ten most beautiful women of 2015. The English actress, model, and activist, Watson took the top spot on the AskMen “Top 99 Outstanding Women 2015″ list and at number 26 on the TIME 100 list of the world's most influential people.
Song “Taste of China” (Phoenix Legend)
I said it last year - and I'll say it again. There is only one activity more thankless than predicting the future - and that is publicly sharing your predictions.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

什么温度的葡萄酒最好喝(图)

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

鲁纳尔说:这颗钻石可能产于南非的普列米尔矿山,现称库里南矿场。”
不过,人们并没有对周二的峰会寄予过高期望,因为没有任何迹象表明,各国能在政治上实现突破,进而采取更有力的举措。科学家表示,要想如愿把全球变暖控制在各国五年前一致同意的上限,那么未来几年里,就必须扭转排放量上升的势头。现有的所有方案,与实现这一目标都相距甚远。
May happiness follow you wherever you go!愿您幸福快乐,直到永远永远。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

日本
Low inflation reflects weakening demand and doesn't inspire confidence about the economic shift from manufacturing to consumption, yet at the same time it should allow Beijing to enact stimulus should it seek to support the economy further .

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

《权力的游戏》
Profits fell by 54 per cent year-on-year to Rmb105.6bn ($15.9bn) during the period, a drop of Rmb124.4bn, according to figures published by the China Insurance Regulatory Commission.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

“像这样的问题是极为紧要的,尽管不一定通过言语表达了出来。”

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

The director Bennett Miller saw Mr. Carell as a good choice to play du Pont but didn’t want him to be too recognizable. He charged the makeup designer Bill Corso with the task of altering Mr. Carell’s look.
卡尔还表示:“就算没有厄尔尼诺现象,去年气温也有可能创纪录,但厄尔尼诺现象让高温更加极端。”
民主党能在中期选举中重新夺回美国众议院多数党地位吗?

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

而在科隆游戏展上正式宣布的特色作品中,《寂静岭》(Silent Hills)的最新续集赫然在列。这是科乐美(Konami)最为畅销的恐怖题材游戏(还据此改编成了两部电影)。世界级游戏和电影专家,《合金装备5:幻痛》(Metal Gear Solid V: The Phantom Pain)的制作者小岛秀夫,以及《环太平洋》(Pacific Rim)的导演吉尔莫o德尔o托罗在这部游戏中强强联手。曾出演美剧《行尸走肉》(The Walking Dead)的影星诺曼o瑞杜斯将在游戏中担纲主角。
In early December, authorities announced that market circuit breakers would be introduced become effective from January 1 in an effort to limit the volatility seen during the savage, summer sell-off from June. The circuit breakers would see trading in shares, options and futures halted for 15 minutes if they fell by more than 5 per cent. On their first day of use, that first threshold was breached just after the return from the lunchbreak, prompting a 15-minute halt.
The companies that have tried — and so far failed — to create a sustained ETF boom in Asia say the need for wholesale reform suggests the market will be defined by a protracted effort to convince both the regulators and customers to redraw the scenery.
据牛津经济研究院(Oxford Economics)估算,若剔除价格影响,中国10月进口量同比降幅为2.6%。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Madison Marriage is accounting and tax correspondent
你是有人脉,是的没错。但是你是在你的业界彻底地撒下关系网这样你说的话又传到你老板耳朵里了。这个世界太小了Andrea Kay说。他是一位职业顾客也是《如何获得下一份工作》这本书的作者。这样的事情经常发生。当你和新老人脉分享你的简历和其他跟找工作相关的材料时,明确地表明你这次找工作是秘密的Foss说。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

这一发现引起了历史学家的极大关注,因为这为了解理查三世提供了更加确凿的证据。理查三世于1485年死于博斯沃思战役,之后有关他的一生一直充满争议。
That price looks excellent given that Tucker should fit more neatly in a three-and-d role than Ross, Sullinger is a total non-factor, and the Raptors kept their own 2017 first-round pick.
退出单向乐队之后,哈里·斯泰尔斯可以去自己想去的任何地方。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

《新财富》预计,2025年左右,中国首富将追平美国首富的个人财富,并有实力问鼎全球首富。
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