Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
8.Please aid the Olympic authorities and organisers by demonstrating at all times that you are not a terrorist. Do not perspire, take off your shoes, smile in a weird way while texting someone, or point and shout: "Hey! Look at all those missiles on that roof over there!" In fact, if you're not using your hands for anything, it's probably best if you keep them in the air where everybody can see them.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
*最佳综艺导演：瑞安?麦克福(Ryan McFaul)，《艾米?舒莫的内心世界》(Inside Amy Schumer)
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels
Hillary stays on: Clinton’s CV is chock full of firsts: The only first lady to become a U.S. senator turned viable presidential candidate turned secretary of state. Now a private citizen, she continues to be one of the most watched and listened-to women on the planet. All bets on that she will be the 2016 Democratic presidential candidate and the free world’s presumptive next leader. She’s done little to quiet the chatter, including hitting the speaking circuit last month at an estimated $200,000 fee per event and inking a reported $14 million book deal.
Having earned a living for the last four years while her contemporaries go to school every day, she has been forced to mature quickly.
Trends and targets in antiviral phototherapy
The most exciting part is the offseason
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
In the past two decades, several campus poisoning incidents have sparked mass debates and concerns about students' psychological development and support.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
这是两部后自语核(post-mumblecore)喜剧，讲述自我认知及其边界的故事。布西内斯克的影片是完美的怪人三角，三条边分别是盖·皮尔斯(Guy Pearce)、寇碧·史莫德斯(Cobie Smulders)和凯文·科利根(Kevin Corrigan)，以德克萨斯州奥斯汀怪人们轻松胡混的伪装出现。皮文的影片探索精神病以及日间电视节目的的黑暗疆域。由于克里斯汀·韦格(Kristen Wiig)的精彩演出（她饰演一个名叫爱丽丝·克里格的彩票得主），《欢迎来到我的世界》成了关于美国梦想者的精彩肖像，既令人不安，也鼓舞人心。
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
'People go crazy and it gets overwhelming.'
The number of people living in poverty in rural areas was reduced by 12.4 million.
Li Jianmin, from the local Public Security Bureau, told Xinhua news agency, quoted by the South China Morning Post: 'The entire processing facility had a fishy and foul smell. You just couldn't stand it after one or two minutes.'
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
McCarthy took home $33 million in earnings, up $10 million from 2015.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
?007 is almost always calm. (Maybe that's due to all the sex.) Even when people are trying to kill him he's calm. This is sexy. Bond doesn't move unnecessarily. You never see his knee bouncing or hands fidgeting. He speaks slowly and deliberately and is rarely rushed. These are all very charismatic qualities. He has the unflinching eye contact of a predator -- and this increases the chance women will fall in love with him. 007 doesn't gush over girls and show his feelings. He keeps them guessing and uncertainty increases attraction. Bond doesn't smile much and this too makes him sexy because happiness isn't alluring in men. His body language is commanding and he's not afraid to take up space, which is very masculine and appealing. 007 doesn't ramble on and this too is smooth. Bond never slouches. Good posture increases confidence, feelings of power and makes you physically tougher. (Which works out well when you want to look classy in your tuxedo while battling machete wielding evil minions.)
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
On Turkey, which recently shot down a Russian warplane, Putin said he sees no possibility of overcoming the strained ties with the current Turkish leadership. He said he was shocked to see that Turkey hadn't tried to explain its action but turned to help from NATO instead.
Antiviral drug discovery: broad-spectrum drugs from nature
For the New Yorkers who have turned their apartments into bed-and-breakfasts, the battle over illegal inns could reach a fever pitch. On top of it all, Mayor Bill de Blasio’s 10-year affordable housing plan will take shape just as legislation in Albany threatens to strain the pocketbooks of renters. These are among the game-changers looming as we ring in the New Year.
The U.S. is set to add nearly 3 million jobs in 2014 — the biggest increase since 1999. The burst in job creation, expected to continue in 2015, is sure to fuel consumer spending. So, too, will a plunge in gasoline prices that's given households extra cash to spare on other goods and services. See: Americans saved $14 billion as gasoline prices declined in 2014.
她和妹妹都是通过家庭辅导接受教育的。她的妹妹也出演了《Dance Moms》。去年，以两姐妹的名字创建的时尚品牌The Maddie & Mackenzie Collection问世。
Influenza neuraminidase: A druggable target for natural products
‘The Americans’ Set in the Reagan era, this FX series is nearly as deceptive as KGB agents posing as suburban American couple: In its second season, “The Americans” proved to be a drama about love, family, friendship and mistrust disguised as a Cold War thriller.
Mr. Russell's 1970s Abscam fictionalization 'American Hustle' had the better night overall, winning acting awards for Amy Adams and Jennifer Lawrence. Best picture was the only award for '12 Years a Slave,' which came in with seven nominations, tied for the most with 'American Hustle.'
At its Worldwide Developer Conference in June, Mr Cook was mobbed by app makers who asked him to pose for selfies. By October’s iPad launch, he was even cracking jokes at his own expense. Clad in his habitual but unglamorous uniform of black untucked shirt and jeans, he said that Apple Watch had been well received by “people who know a lot about fashion and style — even more than I do”, pointing a knowing finger at the chuckling audience.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
In a statement given to the website Kotaku, Epic Games said the lawsuit was a result of Mr Rogers "filing a DMCA counterclaim to a takedown notice on a YouTube video that exposed and promoted Fortnite Battle Royale cheats and exploits."
‘Hackers are using common terms from pop culture and sports to break into accounts online because they know many people are using those easy-to-remember words.’
The role of biosensors in the detection of emerging infectious diseases
The 500 brands come from 28 different countries, among which nearly half, 227, are from the US.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
其实，在第一部iPhone手机发布的前一年，LG集团已经推出了全触屏手机。虽然那也不是第一台触屏手机。1992年，世界上第一台触屏手机IBM Simon发布。而触屏技术在"西蒙"之前已经出现。1965年，E·A·约翰逊发明了第一个触屏设备——平板电脑，截止到1995年，一直由空中交通管制员使用。本特·斯顿普和弗兰克·贝克(Frank Beck)在20世纪70年代早期发明了电容式触屏，与约翰逊所发明触屏不同的是，它不能用手指操作，而是需要使用触控笔。在1971年，山姆·赫斯特发明了第一台电阻式触屏，他称之为"电子图表"。手指和触控笔都可以对它进行操作。在1985年，惠普公司发明了世界上第一台触屏电脑H-P150。在1993年，苹果公司也发布了第一个触屏设备——牛顿个人电子助理设备。但此产品并不成功，它的销量很低。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
I always judge the tank on actions and not by words. So, when teams say they're not in the tank and then run out a bunch of undrafted free agents while injuries to star players linger, that's when you know it's on.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
These are a few old shows that found new vigor in 2014 and deserve another look — and also a few that don’t.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
The clip, taken on a mobile phone, starts with the crowd singing the Frankie Valli lyrics: You're just too good to be true, can't take my eyes off of you'.
China’s handling of its state reserves of raw materials such as cotton and sugar will be a key factor shaping the direction of agricultural commodities in 2017, according to a major lender to agribusinesses.
The rest of the top 10 2016 highest-paid actresses are:
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Chinese billionaire Wang Jianlin, whose company owns AMC Theaters climbed into the top 20.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Perhaps the more interesting question is what drove Yahoo! to shell out that reported $30 million for a single app. To be sure, Summly's text-compression abilities dovetail nicely with Yahoo!'s new focus on mobile utilities. Along with Yahoo!'s $1.1 billion purchase of the blogging service Tumblr and the launch of an acclaimed new weather app, the Summly move marks a commitment to owning the tiny real estate of the smartphone screen-and serving advertising to the youthful eyeballs that tend to gravitate to mobile devices.
The American share in the total drugspending is about one third. IMS experts estimate that in 2014 it will rise11.7 percent. The UShas particularly high prices, according to the report, but drug makers defendthis by citing the soaring cost of new medicine development.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
9月，苹果iPhone 6s和6s Plus发售，在中国创下销售记录。中国占苹果公司总营收的逾四分之一。在这里，苹果的产品往往被视为地位的象征，它的竞争对手不仅有来自韩国的劲敌三星(Samsung)，还有日益流行的中国智能手机品牌华为和小米。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Over the first weekend of 2015 the second-largest bitcoin exchange, Slovenia-based Bitstamp, was victim of a hack to the tune of some $5 million U.S. dollars’ worth of the digital currency. As the tech press were quick to point out, it was a worrisome start to the year for a digital currency that Quartz had already declared “the worst investment of 2014.” And if you look at its performance between Jan 1, 2014 and Jan. 1, 2015, that’s not wrong: bitcoin ended the year at 39% of the value it started with.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Additional reporting from Stefan Wagstyl in Berlin
I'm sure Dwight Howard's never used steroids, but it sure looks like he has. It looks like Howard doubled in size since leaving high school for the NBA.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
That even at a lower profit margin (say, 40%) and a 1/3 cannibalization rate (i.e. customers buy one third fewer full-priced iPhones), the cheaper iPhone would increase Apple'srevenue and gross profits (see her spreadsheet above).
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
WASHINGTON (MarketWatch) — The U.S. economy finally got a big jolt of energy in 2014 after the lamest recovery since World War II. And 2015 is shaping up to be an even better year.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
But the impact of corporate stinginess can go beyond simply ruining employees’ lunar new year holiday, possibly coming back to bite employers: 39 per cent of respondents said they would look for work elsewhere if their year-end bonus was not up to snuff, an increase of 2.3 percentage points from 2015.
Consumer and producer prices are still either muted or in deflationary territory in China – but last month marked something of an uptick for each.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
It is not unusual for the documented wealth of China’s richest people to surge suddenly — or even for previously unknown tycoons to burst into prominence — as stock exchange listings and other public investments thrust them into the spotlight.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
伦敦博蒙特·内森顾问公司(Beaumont Nathan)的联合创始人雨果·内森(Hugo Nathan)说：“新投资者对早期绘画大师的作品有兴趣，不过他们想要的是杜维恩(Duveen)卖给强盗大亨们的作品。他们想要名作。”他指的是英国艺术交易商约瑟夫·杜维恩(Joseph Duveen)，他把很多伟大的艺术品带去了美国。
“…started swearing during the interview.”
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
EMBAGlobal is the only programme in the top 10 that saw a slight drop in the average salary of its alumni compared with last year (the other nine recorded strong increases).
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Dealers: Car dealers work toward reducing the paperwork involved in buying a car and the hours it takes to fill it out. That will give them more time to devote to upselling add-ons such as extended warranties, paint and fabric protection, and rust-proofing.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Islands in China come with many restrictions on their use and just 50 years of ownership.
Best wishes for the holidays and happiness throughout the New Year.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
ESCP Europe and MIT Sloan School of Management in the US also performed well. Both schools climbed five places into third and fifth place respectively.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
What’s more, a Fiat engine not only places among Wards’ top 10 for the first time, it’s for an electric motor, the 83-kW unit found under the hood of the diminutive 500e. Unfortunately the car is only sold in California, though market forces might convince the automaker to send it into wider distribution should gas prices gain spike up to the $4.00/gallon mark or above.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Taken together, these events and strategic initiatives highlight the Chinese aerospace industry’s realization that, in order to become a globally competitive player, it will need depth as much as breadth. After getting their hands on both ends of the value chain—aircraft design and final assembly—the Chinese now understand that what will make or break their industry over the long term is what happens in the middle of the value chain, at the component and subsystem levels. And that is why China’s ambition to compete with Boeing and Airbus, as well as with GE and Rolls-Royce for aircraft engines, is now more credible than ever.
I am so excited to be hosting the Oscars for the second time. You know what they say - the third time's the charm.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
这段深入11岁女孩心灵与情感的旅程可能是皮克斯迄今最疯狂的冒险。这是一部非常有趣的工作场合情景喜剧，艾米·波勒(Amy Poehler)、菲利丝·史密斯(Phyllis Smith)和敏迪·卡灵(Mindy Kaling)等人带来了精彩感人的演出，这是一则关于心理发展的精巧语言，也是对于悲伤在我们的生活中所扮演的角色的一种感人而诚恳的辩护。
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The Harry Potter star Emma Watson hold fifth position in the list of ten most beautiful women of 2015. The English actress, model, and activist, Watson took the top spot on the AskMen “Top 99 Outstanding Women 2015″ list and at number 26 on the TIME 100 list of the world's most influential people.
Song “Taste of China” (Phoenix Legend)
I said it last year - and I'll say it again. There is only one activity more thankless than predicting the future - and that is publicly sharing your predictions.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
May happiness follow you wherever you go!愿您幸福快乐，直到永远永远。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Low inflation reflects weakening demand and doesn't inspire confidence about the economic shift from manufacturing to consumption, yet at the same time it should allow Beijing to enact stimulus should it seek to support the economy further .
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Profits fell by 54 per cent year-on-year to Rmb105.6bn ($15.9bn) during the period, a drop of Rmb124.4bn, according to figures published by the China Insurance Regulatory Commission.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The director Bennett Miller saw Mr. Carell as a good choice to play du Pont but didn’t want him to be too recognizable. He charged the makeup designer Bill Corso with the task of altering Mr. Carell’s look.
Length-scale dependence of protein hydration-shell density
而在科隆游戏展上正式宣布的特色作品中，《寂静岭》（Silent Hills）的最新续集赫然在列。这是科乐美（Konami）最为畅销的恐怖题材游戏（还据此改编成了两部电影）。世界级游戏和电影专家，《合金装备5：幻痛》（Metal Gear Solid V: The Phantom Pain）的制作者小岛秀夫，以及《环太平洋》（Pacific Rim）的导演吉尔莫o德尔o托罗在这部游戏中强强联手。曾出演美剧《行尸走肉》（The Walking Dead）的影星诺曼o瑞杜斯将在游戏中担纲主角。
In early December, authorities announced that market circuit breakers would be introduced become effective from January 1 in an effort to limit the volatility seen during the savage, summer sell-off from June. The circuit breakers would see trading in shares, options and futures halted for 15 minutes if they fell by more than 5 per cent. On their first day of use, that first threshold was breached just after the return from the lunchbreak, prompting a 15-minute halt.
The companies that have tried — and so far failed — to create a sustained ETF boom in Asia say the need for wholesale reform suggests the market will be defined by a protracted effort to convince both the regulators and customers to redraw the scenery.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Madison Marriage is accounting and tax correspondent
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
That price looks excellent given that Tucker should fit more neatly in a three-and-d role than Ross, Sullinger is a total non-factor, and the Raptors kept their own 2017 first-round pick.
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